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Tetrapeptide Supreme Cream

A rich overnight renewal cream powered by Retinatural® Complex and Tetrapeptide-21 to visibly firm, smooth, and deeply replenish skin.

4.8
Rated 4.8 out of 5 stars
300 Reviews
$98 $98 0% savings
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Benefits
  • Firmness
  • Nourishment
  • Renewal
  • Recovery

Powered by Retinatural® Complex and Tetrapeptide-21, this rich overnight cream helps visibly firm skin, smooth the appearance of fine lines, and deeply replenish moisture to support the skin barrier with lasting hydration. Designed for skin experiencing dryness, loss of elasticity, and visible signs of aging, this deeply comforting formula leaves skin looking smoother, more supple, and restored —transforming your nightly routine into a replenishing renewal ritual.

 

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    4.8
    Rated 4.8 out of 5 stars
    Based on 300 reviews
    Reviews Summary
    Customers say this cream provides exceptional hydration for dry skin, particularly as a night moisturizer. Many reviews mention its silky, luxurious texture that absorbs well without feeling greasy. Users appreciate its gentle formula for sensitive skin, with frequent comments about waking up to soft, moisturized skin. While most love the product's performance, some note changes from a previous formula, mentioning differences in scent and texture. The cream receives particular praise from those in dry climates, with many describing it as their long-term favorite moisturizer.
    Rating
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    Age
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    300 reviews
    • Heather C.
      Verified Buyer
      I recommend this product
      Age 45-54
      Your skin type: Normal
      Your skin concerns: Fine Lines & Wrinkles, Uneven Skin Tone, Dullness
      How long have you used the product? Over a month
      Rated 5 out of 5 stars
      8/19/26
      Great Cream!

      This is my favorite facial cream! It works well before makeup or bedtime!

    • Mary B. G.
      Verified Buyer
      I recommend this product
      Age 65+
      Your skin type: Dry
      Your skin concerns: Dryness, Dullness, Fine Lines & Wrinkles, Uneven Skin Tone
      How long have you used the product? Over a month
      Rated 5 out of 5 stars
      8/17/26
      So rich! The best moisturizer ever!

      I have tried other clean moisturizers, but none of them beat tetrapeptide supreme cream! I have dry mature skin, so I need a great moisturizer. I am even more dry during the cold winter months, but this product keeps me moisturized day and night! I love knowing I am helping my skin look at best even as I age!

    • Michelle J.
      Verified Buyer
      I recommend this product
      Age 55-64
      Your skin type: Normal
      Your skin concerns: Fine Lines & Wrinkles
      How long have you used the product? Over a month
      Rated 5 out of 5 stars
      8/10/26
      Fine

      Love everything I have used in the red bottles and jars!!!

      All feels amazing and smells amazing!!

      I feel like all of these products are helping with wrinkles and hydration! I definitely feel like I have less visible age spots

    • Erin G.
      Verified Buyer
      I recommend this product
      Age 35-44
      Your skin type: Combination
      Your skin concerns: Breakouts, Fine Lines & Wrinkles
      How long have you used the product? Over a month
      Rated 5 out of 5 stars
      8/10/26
      Favorite Night Cream

      This is a lightweight, but very effective cream. A little goes a long way, and I've noticed that it really accelerates the healing process when my skin has blemishes.

    • Briana B.
      Verified Buyer
      I recommend this product
      Age 45-54
      Your skin type: Combination
      Your skin concerns: Dryness, Dullness
      How long have you used the product? Over a month
      Rated 5 out of 5 stars
      8/10/26
      Dry skin remedy

      I live in the high desert, after living at sea level for 20 years prior. This cream is critical for my feeling adequately moisturized at 45 in a dry climate. I use it on my eyes as well. Its fantastic. It soaks right in, makes my skin dewy but never greasy, and is just lovely. Highly recommend.